Products

Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

PCSK7

Gene Alias

LPC, PC7, PC8, SPC7

Gene Description

proprotein convertase subtilisin/kexin type 7

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq

Other Designations

lymphoma proprotein convertase|prohormone convertase 8, subtilisin-like|prohormone convertase PC7|proprotein convertase PC7|proprotein convertase subtilisin/kexin type 7 precursor variant 1|subtilisin/kexin-like protease PC7