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Last updated: 2017/11/19

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CBFA2T2 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00009139-T01
  • Visit Frequency :
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-CBFA2T2 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 63.36
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-CBFA2T2 antibody (H00009139-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00009139-T01
    CBFA2T2 transfected lysate.
    Western Blot
    QC Testing of H00009139-T01
    Lane 1: CBFA2T2 transfected lysate ( 63.36 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 9139
  • Gene Name:
  • CBFA2T2
  • Gene Alias:
  • DKFZp313F2116,EHT,MTGR1,ZMYND3
  • Gene Description:
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2
  • Gene Summary:
  • In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq
  • Other Designations:
  • ETO homolog on chromosome 20,MTG8-like protein,OTTHUMP00000030653,myeloid translocation gene-related protein 1
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