CBFA2T2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
CBFA2T2 transfected lysate.
Western Blot
Lane 1: CBFA2T2 transfected lysate ( 63.36 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CBFA2T2 full-length
Host
Human
Theoretical MW (kDa)
63.36
Interspecies Antigen Sequence
Mouse (95); Rat (94)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CBFA2T2 antibody (H00009139-B01) by Western Blots.
SDS-PAGE Gel
CBFA2T2 transfected lysate.
Western Blot
Lane 1: CBFA2T2 transfected lysate ( 63.36 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CBFA2T2
Entrez GeneID
9139GeneBank Accession#
NM_001039709.1Protein Accession#
NP_001034798.1Gene Name
CBFA2T2
Gene Alias
DKFZp313F2116, EHT, MTGR1, ZMYND3
Gene Description
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Omim ID
603672Gene Ontology
HyperlinkGene Summary
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq
Other Designations
ETO homolog on chromosome 20|MTG8-like protein|OTTHUMP00000030653|myeloid translocation gene-related protein 1
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