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Last updated: 2016/10/16
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CBFA2T2 purified MaxPab mouse polyclonal antibody (B01P)MaxPab

  • Catalog # : H00009139-B01P
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  • Specification
  • Product Description:
  • Mouse polyclonal antibody raised against a full-length human CBFA2T2 protein.
  • Immunogen:
  • CBFA2T2 (NP_001034798.1, 1 a.a. ~ 575 a.a) full-length human protein.
  • Sequence:
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Antibody reactive against mammalian transfected lysate.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • CBFA2T2 MaxPab polyclonal antibody. Western Blot analysis of CBFA2T2 expression in human colon.
  • PDF DownloadProtocol Download
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western Blot analysis of CBFA2T2 expression in transfected 293T cell line (H00009139-T01) by CBFA2T2 MaxPab polyclonal antibody.

    Lane 1: CBFA2T2 transfected lysate(63.25 KDa).
    Lane 2: Non-transfected lysate.
  • PDF DownloadProtocol Download
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 9139
  • Gene Name:
  • CBFA2T2
  • Gene Alias:
  • DKFZp313F2116,EHT,MTGR1,ZMYND3
  • Gene Description:
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2
  • Gene Summary:
  • In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq
  • Other Designations:
  • ETO homolog on chromosome 20,MTG8-like protein,OTTHUMP00000030653,myeloid translocation gene-related protein 1
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