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LATS1 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00009113-T02
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-LATS1 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 126.9
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-LATS1 antibody (H00009113-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00009113-T02
    LATS1 transfected lysate.
    Western Blot
    QC Testing of H00009113-T02
    Lane 1: LATS1 transfected lysate ( 126.90 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 9113
  • Gene Name:
  • LATS1
  • Gene Alias:
  • WARTS,wts
  • Gene Description:
  • LATS, large tumor suppressor, homolog 1 (Drosophila)
  • Gene Summary:
  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq
  • Other Designations:
  • LATS (large tumor suppressor, Drosophila) homolog 1,LATS homolog 1
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