Products

Western Blot (Transfected lysate)

Immunofluorescence

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

MTA1

Gene Alias

-

Gene Description

metastasis associated 1

Omim ID

Gene Ontology

Gene Summary

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. [provided by RefSeq

Other Designations

metastasis associated gene 1 protein|metastasis associated protein