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Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

SART1

Gene Alias

Ara1, HOMS1, MGC2038, SART1259, SNRNP110, Snu66

Gene Description

squamous cell carcinoma antigen recognized by T cells

Omim ID

Gene Ontology

Gene Summary

This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq

Other Designations

IgE autoantigen|SART1(259) protein|SART1(800) protein|U4/U6.U5 tri-snRNP-associated 110 kDa protein|small nuclear ribonucleoprotein 110kDa (U4/U6.U5)|squamous cell carcinoma antigen recognised by T cells|squamous cell carcinoma antigen recognized by T cel