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SART1 rabbit monoclonal antibody

  • Catalog # : H00009092-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human SART1 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human SART1 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human SART1 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 9092
  • GeneBank Accession#:
  • SART1
  • Gene Name:
  • SART1
  • Gene Alias:
  • Ara1,HOMS1,MGC2038,SART1259,SNRNP110,Snu66
  • Gene Description:
  • squamous cell carcinoma antigen recognized by T cells
  • Gene Summary:
  • This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq
  • Other Designations:
  • IgE autoantigen,SART1(259) protein,SART1(800) protein,U4/U6.U5 tri-snRNP-associated 110 kDa protein,small nuclear ribonucleoprotein 110kDa (U4/U6.U5),squamous cell carcinoma antigen recognised by T cells,squamous cell carcinoma antigen recognized by T cel
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