PKMYT1 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of PKMYT1 expression in transfected 293T cell line (H00009088-T01) by PKMYT1 MaxPab polyclonal antibody.
Lane 1: PKMYT1 transfected lysate(54.89 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human PKMYT1 protein.
Immunogen
PKMYT1 (NP_004194.3, 1 a.a. ~ 499 a.a) full-length human protein.
Sequence
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (89); Rat (89)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of PKMYT1 expression in transfected 293T cell line (H00009088-T01) by PKMYT1 MaxPab polyclonal antibody.
Lane 1: PKMYT1 transfected lysate(54.89 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — PKMYT1
Entrez GeneID
9088GeneBank Accession#
NM_004203.3Protein Accession#
NP_004194.3Gene Name
PKMYT1
Gene Alias
DKFZp547K1610, FLJ20093, MYT1
Gene Description
protein kinase, membrane associated tyrosine/threonine 1
Omim ID
602474Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase|protein kinase Myt1
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Interactome
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Pathway
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Publication Reference
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Targeting ODF2L is synthetic lethal with WEE1 kinase inhibition in epithelial ovarian cancer models.
Jie Li, Jingyi Lu, Manman Xu, Shiyu Yang, Tiantian Yu, Cuimiao Zheng, Xi Huang, Yuwen Pan, Yangyang Chen, Junming Long, Chunyu Zhang, Hua Huang, Qingyuan Dai, Bo Li, Wei Wang, Shuzhong Yao, Chaoyun Pan.
The Journal of Clinical Investigation 2022 Nov; e161544.
Application：WB-Ce, Human, A2780, SKOV3 cells.
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Targeting ODF2L is synthetic lethal with WEE1 kinase inhibition in epithelial ovarian cancer models.
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