PSTPIP1 monoclonal antibody (M02), clone 1D5
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant PSTPIP1.
Immunogen
PSTPIP1 (AAH08602, 1 a.a. ~ 416 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MMPQLQFKDAFWCRDFTAHTGYEVLLQRLLDGRKMCKDMEELLRQRAQAEERYGKELVQIARKAGGQTEINSLRASFDSLKQQMENVGSSHIQLALTLREELRSLEEFRERQKEQRKKYEAVMDRVQKSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANGHQKQVEKSQNKARQCKDSATEAERVYRQSIAQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSNQLSMQCVKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPAPVPYQNYYDREVTPLTSSPGIQPSCGMIKRFSGLLHGSPKTTSLAASAASTETLTPTPERNEGVYTAIAVQEIQGNPASPAQEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYLEKL
Host
Mouse
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (87); Rat (86)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (71.5 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
PSTPIP1 monoclonal antibody (M02), clone 1D5. Western Blot analysis of PSTPIP1 expression in Raw 264.7(Cat # L024V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PSTPIP1 is 1 ng/ml as a capture antibody.ELISA
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Gene Info — PSTPIP1
Entrez GeneID
9051GeneBank Accession#
BC008602Protein Accession#
AAH08602Gene Name
PSTPIP1
Gene Alias
CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP
Gene Description
proline-serine-threonine phosphatase interacting protein 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq
Other Designations
CD2 antigen-binding protein 1|CD2 cytoplasmic tail-binding protein|PEST phosphatase-interacting protein 1
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Interactome
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Disease
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Publication Reference
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A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever.
Moghaddas F, Llamas R, De Nardo D, Martinez-Banaclocha H, Martinez-Garcia JJ, Mesa-Del-Castillo P, Baker PJ, Gargallo V, Mensa-Vilaro A, Canna S, Wicks IP, Pelegrin P, Arostegui JI, Masters SL.
Annals of the Rheumatic Diseases 2017 Aug; 76(12):2085.
Application:WB-Tr, Human, HEK 293T cells.
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BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts.
Sztacho M, Segeletz S, Sanchez-Fernandez MA, Czupalla C, Niehage C, Hoflack B.
PLoS One 2016 Oct; 11(10):e0164829.
Application:WB, Mouse, Raw 264.7 cells.
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A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever.
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