CH25H monoclonal antibody (M01), clone 1G8
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More Files
- More Functions
Western Blot detection against Immunogen (37.29 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant CH25H.
Immunogen
CH25H (AAH17843.1, 142 a.a. ~ 247 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
WHLLHHKVPWLYRTFHKVHHQNSSSFALATQYMSVWELFSLGFFDMMNVTLLGCHPLTTLTFHVVNIWLSVEDHSGYNFPWSTHRLVPFGWYGGVVHHDLHHSHFN
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (78); Rat (81)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.29 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — CH25H
Entrez GeneID
9023GeneBank Accession#
BC017843Protein Accession#
AAH17843.1Gene Name
CH25H
Gene Alias
C25H
Gene Description
cholesterol 25-hydroxylase
Omim ID
604551Gene Ontology
HyperlinkGene Summary
This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. [provided by RefSeq
Other Designations
OTTHUMP00000020057
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Interactome
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Pathway
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Disease
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Publication Reference
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Lung-selective 25-hydroxycholesterol nanotherapeutics as a suppressor of COVID-19-associated cytokine storm.
Hyelim Kim, Han Sol Lee, June Hong Ahn, Kyung Soo Hong, Jong Geol Jang, Jiseon An, Yong-Hyeon Mun, So-Yeol Yoo, Yoon Jung Choi, Mi-Young Yun, Gyu Yong Song, Jinmyoung Joo, Dong Hee Na, Hong Nam Kim, Hee Ho Park, Jae-Young Lee, Wonhwa Lee
Nano Today 2021 Apr; 38:101149.
Application：WB, Human, PBMCs.
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Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry.
Yuan Y, Wang Z, Tian B, Zhou M, Fu ZF, Zhao L.
Archives of Virology 2019 Dec; 164(12):2963.
Application：IF, WB-Ti, WB-Tr, Human, Mouse, Brain, 293T cells.
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Lung-selective 25-hydroxycholesterol nanotherapeutics as a suppressor of COVID-19-associated cytokine storm.
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