F2RL3 monoclonal antibody (M01), clone 5F4
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant F2RL3.
Immunogen
F2RL3 (NP_003941, 18 a.a. ~ 82 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
GGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (60); Rat (57)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (32.89 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged F2RL3 is approximately 0.03ng/ml as a capture antibody.ELISA
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Gene Info — F2RL3
Entrez GeneID
9002GeneBank Accession#
NM_003950Protein Accession#
NP_003941Gene Name
F2RL3
Gene Alias
PAR4
Gene Description
coagulation factor II (thrombin) receptor-like 3
Omim ID
602779Gene Ontology
HyperlinkGene Summary
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq
Other Designations
protease-activated receptor-4|proteinase-activated receptor-4
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Interactome
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Pathway
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Disease
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Publication Reference
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A cluster of aspartic residues in the extracellular loop II of PAR 4 is important for thrombin interaction and activation of platelets.
Sánchez Centellas D, Gudlur S, Vicente-Carrillo A, Ramström S, Lindahl TL.
Thrombosis Research 2017 Apr; 154:84.
Application:WB, Antibody.
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Polymorphism in the protease activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury.
Muehlschlegel JD, Perry TE, Liu KY, Fox AA, Smith S, Lichtner P, Collard CD, Shernan SK, Hartwig JH, Body SC, Hoffmeister KM.
American Journal of Hematology 2012 Feb; 87(2):161.
Application:Flow Cyt, Human, Platelet.
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A cluster of aspartic residues in the extracellular loop II of PAR 4 is important for thrombin interaction and activation of platelets.
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