ATP6V0E (Human) Recombinant Protein (P01)
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Specification
Product Description
Human ATP6V0E full-length ORF ( NP_003936.1, 1 a.a. - 81 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAYHGLTVPLIVMSVFWGFVGFLVPWFIPKGPNRGVIITMLVTCSVCCYLFWLIAILAQLNPLFGPQLKNETIWYLKYHWP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
35.8
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ATP6V0E1
Entrez GeneID
8992GeneBank Accession#
NM_003945.3Protein Accession#
NP_003936.1Gene Name
ATP6V0E1
Gene Alias
ATP6H, ATP6V0E, M9.2, Vma21, Vma21p
Gene Description
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
Omim ID
603931Gene Ontology
HyperlinkGene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq
Other Designations
ATPase, H+ transporting, lysosomal (vacuolar proton pump) 9kD|ATPase, H+ transporting, lysosomal 9kD V0 subunit M9.2|ATPase, H+ transporting, lysosomal 9kD V0 subunit e|ATPase, H+ transporting, lysosomal, 9kD|H(+)-transporting two-sector ATPase, subunit H
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Interactome
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Pathway
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