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MBD4 Pre-design Chimera RNAi

  • Catalog # : H00008930-R01
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  • Specification
  • Product Description:
  • Homo sapiens methyl-CpG binding domain protein 4 (MBD4), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_003925
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 8930
  • Gene Name:
  • MBD4
  • Gene Alias:
  • MED1
  • Gene Description:
  • methyl-CpG binding domain protein 4
  • Gene Summary:
  • DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. [provided by RefSeq
  • Other Designations:
  • 3,N(4)-ethenocytosine glycosylase,G/5-fluorouracil mismatch glycosylase with biphasic kinetics,G/T mismatch glycosylase,G/U mismatch glycosylase,putative methyl-CpG binding protein
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