Western blot analysis of FUBP1 over-expressed 293 cell line, cotransfected with FUBP1 Validated Chimera RNAi ( Cat # H00008880-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with FUBP1 monoclonal antibody (M01), clone 3H4 (Cat # H00008880-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase. [provided by RefSeq
DNA helicase V,FUSE-binding protein,OTTHUMP00000038483,far upstream element binding protein,far upstream element-binding protein