SPHK1 (Human) IP-WB Antibody Pair
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More Files
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Immunoprecipitation of SPHK1 transfected lysate using rabbit polyclonal anti-SPHK1 and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-SPHK1.
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Specification
Product Description
This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
Reactivity
Human
Interspecies Antigen Sequence
Mouse (81); Rat (78)
Quality Control Testing
Immunoprecipitation-Western Blot (IP-WB)
Immunoprecipitation of SPHK1 transfected lysate using rabbit polyclonal anti-SPHK1 and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-SPHK1.
Supplied Product
Antibody pair set content:
1. Antibody pair for IP: rabbit polyclonal anti-SPHK1 (300 ul)
2. Antibody pair for WB: mouse purified polyclonal anti-SPHK1 (50 ug)
Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
Immunoprecipitation-Western Blot
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Gene Info — SPHK1
Entrez GeneID
8877Gene Name
SPHK1
Gene Alias
SPHK
Gene Description
sphingosine kinase 1
Omim ID
603730Gene Ontology
HyperlinkGene Summary
Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.[supplied by OMIM
Other Designations
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Interactome
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Pathway
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