NR1I2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-NR1I2 full-length
Host
Human
Theoretical MW (kDa)
47.85
Interspecies Antigen Sequence
Mouse (77); Rat (76)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-NR1I2 antibody (H00008856-B01) by Western Blots.
SDS-PAGE Gel
NR1I2 transfected lysate.
Western Blot
Lane 1: NR1I2 transfected lysate ( 47.85 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — NR1I2
Entrez GeneID
8856GeneBank Accession#
NM_003889.2Protein Accession#
-Gene Name
NR1I2
Gene Alias
BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Gene Description
nuclear receptor subfamily 1, group I, member 2
Omim ID
603065Gene Ontology
HyperlinkGene Summary
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq
Other Designations
orphan nuclear receptor PXR|steroid and xenobiotic receptor
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Interactome
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Disease
- Anemia
- Asthma
- Birth Weight
- Bone Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Cardiovascular Diseases
- Cholangitis
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