Products

Western Blot (Transfected lysate)

Western Blot analysis of CDK5R1 expression in transfected 293T cell line by CDK5R1 monoclonal antibody (M01), clone 4G11.

Lane 1: CDK5R1 transfected lysate(34.1 KDa).
Lane 2: Non-transfected lysate.

Western Blot (Recombinant protein)

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged CDK5R1 is approximately 0.3ng/ml as a capture antibody.

ELISA

Immunofluorescence

Immunofluorescence of monoclonal antibody to CDK5R1 on HeLa cell . [antibody concentration 10 ug/ml]

Entrez GeneID

8851

GeneBank Accession#

BC020580

Protein Accession#

AAH20580

Gene Name

CDK5R1

Gene Alias

CDK5P35, CDK5R, MGC33831, NCK5A, p23, p25, p35, p35nck5a

Gene Description

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Omim ID

603460

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq

Other Designations

CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|cyclin-dependent kinase 5, regulatory subunit 1|neuronal CDK5 activator|regulatory partner for CDK5 kinase|tau protein kinase II 23kDa subunit