WISP1 DNAxPab
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human WISP1 DNA using DNAx™ Immune technology.
Technology
Immunogen
WISP1 (NP_543028.1, 23 a.a. ~ 280 a.a) partial-length human DNA
Sequence
MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAHAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIAN
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of WISP1 expression in transfected 293T cell line by WISP1 DNAxPab polyclonal antibody.
Lane 1: WISP1 transfected lysate(49.5 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — WISP1
Entrez GeneID
8840GeneBank Accession#
NM_080838.1Protein Accession#
NP_543028.1Gene Name
WISP1
Gene Alias
CCN4, WISP1c, WISP1i, WISP1tc
Gene Description
WNT1 inducible signaling pathway protein 1
Omim ID
603398Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq
Other Designations
WNT1 induced secreted protein 1|Wnt-1 inducible signaling pathway protein 1|wnt-1 signaling pathway protein 1
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Interactome
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Disease
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