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WISP1 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00008840-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-WISP1 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 30.91
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-WISP1 antibody (H00008840-B01) by Western Blots.
    Western Blot
    QC Testing of H00008840-T01
    Lane 1: WISP1 transfected lysate ( 30.7 KDa)
    Lane 2: Non-transfected lysate.
    SDS-PAGE Gel
    QC Testing of H00008840-T01
    WISP1 transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 8840
  • Gene Name:
  • WISP1
  • Gene Alias:
  • CCN4,WISP1c,WISP1i,WISP1tc
  • Gene Description:
  • WNT1 inducible signaling pathway protein 1
  • Gene Summary:
  • This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq
  • Other Designations:
  • WNT1 induced secreted protein 1,Wnt-1 inducible signaling pathway protein 1,wnt-1 signaling pathway protein 1
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