WISP2 MaxPab rabbit polyclonal antibody (D01)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human WISP2 protein.
Immunogen
WISP2 (NP_003872.1, 1 a.a. ~ 250 a.a) full-length human protein.
Sequence
MRGTPKTHLLAFSLLCLLSKVRTQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF
Host
Rabbit
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (72); Rat (70)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
WISP2 MaxPab rabbit polyclonal antibody. Western Blot analysis of WISP2 expression in mouse liver.Immunoprecipitation
Immunoprecipitation of WISP2 transfected lysate using anti-WISP2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with WISP2 MaxPab mouse polyclonal antibody (B01) (H00008839-B01). -
Gene Info — WISP2
Entrez GeneID
8839GeneBank Accession#
NM_003881.2Protein Accession#
NP_003872.1Gene Name
WISP2
Gene Alias
CCN5, CT58, CTGF-L
Gene Description
WNT1 inducible signaling pathway protein 2
Omim ID
603399Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq
Other Designations
OTTHUMP00000031770|OTTHUMP00000063227|connective tissue growth factor-like protein|wnt-1 signaling pathway protein 2
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Interactome
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Publication Reference
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Identification of novel adipokines in the joint. Differential expression in healthy and osteoarthritis tissues.
Conde J, Scotece M, Abella V, Gomez R, Lopez V, Villar R, Hermida M, Pino J, Gomez-Reino JJ, Gualillo O.
PLoS One 2015 Apr; 10(4):e0123601.
Application:WB-Ti, Human, Osteoarthritis chondrocytes.
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Identification of novel adipokines in the joint. Differential expression in healthy and osteoarthritis tissues.
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