SOCS2 polyclonal antibody (A01)
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More Files
- More Functions
Western Blot detection against Immunogen (37 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant SOCS2.
Immunogen
SOCS2 (AAH10399, 99 a.a. ~ 198 a.a) partial recombinant protein with GST tag.
Sequence
YQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYLEEYKFQV
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (93); Rat (93)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — SOCS2
Entrez GeneID
8835GeneBank Accession#
BC010399Protein Accession#
AAH10399Gene Name
SOCS2
Gene Alias
CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
Gene Description
suppressor of cytokine signaling 2
Omim ID
605117Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. [provided by RefSeq
Other Designations
STAT induced STAT inhibitor-2|cytokine-inducible SH2 protein 2|suppressor of cytokine signaling-2
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Interactome
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Pathway
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Disease
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Publication Reference
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Effect of Ovariectomy on Cardiac Gene Expression: Inflammation and Changes in SOCS Genes Expression.
Hamilton KL, Lin L, Wang Y, Knowlton AA.
Physiological Genomics 2007 Nov; 32(2):254.
Application：WB, Rat, Rat left ventricular tissue.
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Effect of Ovariectomy on Cardiac Gene Expression: Inflammation and Changes in SOCS Genes Expression.
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