CES2 monoclonal antibody (M01), clone 2H7
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant CES2.
Immunogen
CES2 (NP_003860, 514 a.a. ~ 621 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHT
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (72); Rat (73)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.62 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
CES2 monoclonal antibody (M01), clone 2H7. Western Blot analysis of CES2 expression in HepG2 ( Cat # L019V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CES2 is approximately 1ng/ml as a capture antibody.ELISA
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Gene Info — CES2
Entrez GeneID
8824GeneBank Accession#
NM_003869Protein Accession#
NP_003860Gene Name
CES2
Gene Alias
CE-2, CES2A1, PCE-2, iCE
Gene Description
carboxylesterase 2 (intestine, liver)
Omim ID
605278Gene Ontology
HyperlinkGene Summary
Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
carboxylesterase 2|intestinal carboxylesterase; liver carboxylesterase-2
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Interactome
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Pathway
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Disease
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