Immunoprecipitation of TNFRSF10B transfected lysate using anti-TNFRSF10B MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with TNFRSF10B MaxPab mouse polyclonal antibody (B01) (H00008795-B01).
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq