Western blot analysis of TNFRSF18 over-expressed 293 cell line, cotransfected with TNFRSF18 Validated Chimera RNAi ( Cat # H00008784-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with TNFRSF18 monoclonal antibody (M02), clone 1D8 (Cat # H00008784-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
OTTHUMP00000001519,OTTHUMP00000001520,OTTHUMP00000001521,TNF receptor superfamily activation-inducible protein,activation-inducible TNFR family receptor,glucocorticoid-induced TNFR-related protein