SNAP23 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-SNAP23 full-length
Host
Human
Theoretical MW (kDa)
23.4
Interspecies Antigen Sequence
Mouse (82); Rat (87)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-SNAP23 antibody (H00008773-D01P) by Western Blots.
SDS-PAGE Gel
SNAP23 transfected lysate.
Western Blot
Lane 1: SNAP23 transfected lysate ( 23.40 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — SNAP23
Entrez GeneID
8773GeneBank Accession#
NM_003825.2Protein Accession#
NP_003816.2Gene Name
SNAP23
Gene Alias
HsT17016, SNAP23A, SNAP23B
Gene Description
synaptosomal-associated protein, 23kDa
Omim ID
602534Gene Ontology
HyperlinkGene Summary
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000161263|synaptosomal-associated protein 23
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