TNFRSF6B monoclonal antibody (M02), clone 7G5
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant TNFRSF6B.
Immunogen
TNFRSF6B (NP_116563, 32 a.a. ~ 141 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
ETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAP
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.84 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to TNFRSF6B on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TNFRSF6B is approximately 0.1ng/ml as a capture antibody.ELISA
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Gene Info — TNFRSF6B
Entrez GeneID
8771GeneBank Accession#
NM_032945Protein Accession#
NP_116563Gene Name
TNFRSF6B
Gene Alias
DCR3, DJ583P15.1.1, M68, TR6
Gene Description
tumor necrosis factor receptor superfamily, member 6b, decoy
Omim ID
603361Gene Ontology
HyperlinkGene Summary
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000031583|decoy receptor 3|tumor necrosis factor receptor superfamily, member 6b
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Interactome
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Pathway
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Disease
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Publication Reference
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EGFR-driven up-regulation of decoy receptor 3 in keratinocytes contributes to the pathogenesis of psoriasis.
Wu NL, Huang DY, Hsieh SL, Hsiao CH, Lee TA, Lin WW.
Biochimica et Biophysica Acta 2013 Oct; 1832(10):1538.
Application:IHC-P, Human, Skin.
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EGFR-driven up-regulation of decoy receptor 3 in keratinocytes contributes to the pathogenesis of psoriasis.
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