This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq
Other Designations:
CARD-carrying kinase,CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase,growth-inhibiting gene 30,receptor interacting protein 2,receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP