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TNFSF10 Pre-design Chimera RNAi

  • Catalog # : H00008743-R01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_003810
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 8743
  • Gene Name:
  • TNFSF10
  • Gene Alias:
  • APO2L,Apo-2L,CD253,TL2,TRAIL
  • Gene Description:
  • tumor necrosis factor (ligand) superfamily, member 10
  • Gene Summary:
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. [provided by RefSeq
  • Other Designations:
  • Apo-2 ligand,TNF-related apoptosis inducing ligand TRAIL,tumor necrosis factor (ligand) family, member 10,tumor necrosis factor apoptosis-inducing ligand splice variant delta
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