TNFSF12 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
SDS-PAGE Gel
TNFSF12 transfected lysate.
Western Blot
Lane 1: TNFSF12 transfected lysate ( 14.85 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-TNFSF12 full-length
Host
Human
Theoretical MW (kDa)
14.85
Interspecies Antigen Sequence
Mouse (84); Rat (81)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-TNFSF12 antibody (H00008742-B01) by Western Blots.
SDS-PAGE Gel
TNFSF12 transfected lysate.
Western Blot
Lane 1: TNFSF12 transfected lysate ( 14.85 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — TNFSF12
Entrez GeneID
8742GeneBank Accession#
BC071837Protein Accession#
AAH71837Gene Name
TNFSF12
Gene Alias
APO3L, DR3LG, MGC129581, MGC20669, TWEAK
Gene Description
tumor necrosis factor (ligand) superfamily, member 12
Omim ID
602695Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Some transcripts that skip the last exon of this gene and continue with the second exon of the neighboring TNFSF13 gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq
Other Designations
APO3/DR3 ligand|TNF-related WEAK inducer of apoptosis
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Interactome
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Pathway
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Disease
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