TNFSF13 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human TNFSF13 full-length ORF ( AAH08042, 1 a.a. - 247 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
52.91
Interspecies Antigen Sequence
Mouse (81); Rat (79)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — TNFSF13
Entrez GeneID
8741GeneBank Accession#
BC008042Protein Accession#
AAH08042Gene Name
TNFSF13
Gene Alias
APRIL, CD256, TALL2, TRDL-1, UNQ383/PRO715, ligand
Gene Description
tumor necrosis factor (ligand) superfamily, member 13
Omim ID
604472Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Other transcripts that skip the last exon of the upstream gene (TNFSF12) and continue with the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq
Other Designations
OTTHUMP00000174780|TNF- and APOL-related leukocyte expressed ligand 2|a proliferation inducing ligand|tumor necrosis factor (ligand) superfamily member 13 transcript variant delta|tumor necrosis factor ligand superfamily member 13 epsilon|tumor necrosis f
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Interactome
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Pathway
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Disease
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Publication Reference
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Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica.
Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Toda T, Yamamura T.
Proceedings of the National Academy of Sciences of the United States of America 2011 Mar; 108(9):3701.
Application:Func, Human, B cells.
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Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica.
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