MYOM1 monoclonal antibody (M01), clone 4F5
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant MYOM1.
Immunogen
MYOM1 (NP_003794.2, 1586 a.a. ~ 1684 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
EGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADSGKYGLVVKNKYGSETSDFTVSVFIPEEEARMAALESLKGGKKA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (84); Rat (84)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged MYOM1 is 0.03 ng/ml as a capture antibody.ELISA
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Gene Info — MYOM1
Entrez GeneID
8736GeneBank Accession#
NM_003803Protein Accession#
NP_003794.2Gene Name
MYOM1
Gene Alias
MGC134946, MGC134947, SKELEMIN
Gene Description
myomesin 1, 185kDa
Omim ID
603508Gene Ontology
HyperlinkGene Summary
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
190 kDa connectin-associated protein|190 kDa titin-associated protein|EH-myomesin|myomesin (M-protein) 1 (190kD)|myomesin 1|myomesin 1 (skelemin) (185kD)|myomesin 1 (skelemin) 185kDa
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Interactome
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Disease
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