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Last updated: 2017/12/10

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MBTPS1 Pre-design Chimera RNAi

  • Catalog # : H00008720-R02
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens membrane-bound transcription factor peptidase, site 1 (MBTPS1), transcript variant 2, mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_201268
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.
    The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 8720
  • Gene Name:
  • MBTPS1
  • Gene Alias:
  • KIAA0091,MGC138711,MGC138712,PCSK8,S1P,SKI-1
  • Gene Description:
  • membrane-bound transcription factor peptidase, site 1
  • Gene Summary:
  • The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. [provided by RefSeq
  • Other Designations:
  • membrane-bound transcription factor protease, site 1,membrane-bound transcription factor site-1 protease,site-1 protease,subtilisin/kexin isozyme-1
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