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Last updated: 2017/1/15

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MBTPS1 rabbit monoclonal antibody

  • Catalog # : H00008720-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human MBTPS1 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human MBTPS1 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human MBTPS1 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 8720
  • Gene Name:
  • MBTPS1
  • Gene Alias:
  • KIAA0091,MGC138711,MGC138712,PCSK8,S1P,SKI-1
  • Gene Description:
  • membrane-bound transcription factor peptidase, site 1
  • Gene Summary:
  • The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. [provided by RefSeq
  • Other Designations:
  • membrane-bound transcription factor protease, site 1,membrane-bound transcription factor site-1 protease,site-1 protease,subtilisin/kexin isozyme-1
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