TNFRSF25 monoclonal antibody (M06), clone 4E3
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant TNFRSF25.
Immunogen
TNFRSF25 (NP_003781, 28 a.a. ~ 124 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
TRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKPGWFVE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (66); Rat (62)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.41 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TNFRSF25 is approximately 1ng/ml as a capture antibody.ELISA
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Gene Info — TNFRSF25
Entrez GeneID
8718GeneBank Accession#
NM_003790Protein Accession#
NP_003781Gene Name
TNFRSF25
Gene Alias
APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR
Gene Description
tumor necrosis factor receptor superfamily, member 25
Omim ID
603366Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq
Other Designations
OTTHUMP00000000922|OTTHUMP00000000925|apoptosis inducing receptor|apoptosis-mediating receptor|death domain receptor 3 soluble form|death receptor beta|lymphocyte associated receptor of death|translocating chain-association membrane protein|tumor necrosis
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Interactome
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Disease
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