TRADD monoclonal antibody (M03), clone 3G3
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More Files
- More Functions
Immunoprecipitation
Immunoprecipitation of TRADD transfected lysate using anti-TRADD monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with TRADD MaxPab rabbit polyclonal antibody.
Western Blot detection against Immunogen (37.84 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant TRADD.
Immunogen
TRADD (NP_003780, 203 a.a. ~ 312 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
LFQGQPVVNRPLSLKDQQTFARSVGLKWRKVGRSLQRGCRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAEDLLGLTDPNGGLA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (89); Rat (87)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.84 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunoprecipitation
Immunoprecipitation of TRADD transfected lysate using anti-TRADD monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with TRADD MaxPab rabbit polyclonal antibody.ELISA
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Gene Info — TRADD
Entrez GeneID
8717GeneBank Accession#
NM_003789Protein Accession#
NP_003780Gene Name
TRADD
Gene Alias
Hs.89862, MGC11078
Gene Description
TNFRSF1A-associated via death domain
Omim ID
603500Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq
Other Designations
TNFR1-associated death domain protein|tumor necrosis factor receptor type 1 associated death domain protein|tumor necrosis factor receptor-1-associated protein
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Interactome
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Pathway
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Disease
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