DYNLL1 DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human DYNLL1 DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — DYNLL1
Entrez GeneID
8655GeneBank Accession#
NM_003746.2Protein Accession#
NP_003737.1Gene Name
DYNLL1
Gene Alias
DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, MGC126137, MGC126138, PIN, hdlc1
Gene Description
dynein, light chain, LC8-type 1
Omim ID
601562Gene Ontology
HyperlinkGene Summary
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq
Other Designations
8 kDa dynein light chain|cytoplasmic dynein light polypeptide|dynein light chain 1|dynein, cytoplasmic, light polypeptide 1|protein inhibitor of neuronal nitric oxide synthase
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Interactome
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Disease
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