PDE5A (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human PDE5A partial ORF ( NP_001074, 29 a.a. - 138 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
SVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSVPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (88); Rat (86)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PDE5A
Entrez GeneID
8654GeneBank Accession#
NM_001083Protein Accession#
NP_001074Gene Name
PDE5A
Gene Alias
CGB-PDE, CN5A, PDE5, PDE5A1
Gene Description
phosphodiesterase 5A, cGMP-specific
Omim ID
603310Gene Ontology
HyperlinkGene Summary
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase|phosphodiesterase 5A
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