PDE5A monoclonal antibody (M01), clone 9H5
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More Files
- More Functions
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PDE5A is 1 ng/ml as a capture antibody.
Immunofluorescence
Immunofluorescence of monoclonal antibody to PDE5A on HeLa cell . [antibody concentration 20 ug/ml]
Western Blot detection against Immunogen (37.84 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant PDE5A.
Immunogen
PDE5A (NP_001074, 29 a.a. ~ 138 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
SVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSVPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (88); Rat (86)
Isotype
IgG3 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.84 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PDE5A is 1 ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to PDE5A on HeLa cell . [antibody concentration 20 ug/ml] -
Gene Info — PDE5A
Entrez GeneID
8654GeneBank Accession#
NM_001083Protein Accession#
NP_001074Gene Name
PDE5A
Gene Alias
CGB-PDE, CN5A, PDE5, PDE5A1
Gene Description
phosphodiesterase 5A, cGMP-specific
Omim ID
603310Gene Ontology
HyperlinkGene Summary
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase|phosphodiesterase 5A
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Interactome
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Pathway
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Disease
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Publication Reference
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Effects and mechanisms of action of sildenafil citrate in human chorionic arteries.
Maharaj CH, O'Toole D, Lynch T, Carney J, Jarman J, Higgins BD, Morrison JJ, Laffey JG.
Reproductive Biology and Endocrinology 2009 Apr; 7:34.
Application：IF, IHC-Fr, WB, Plant, Freshly dissected chorionic plate arterial rings.
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Effects and mechanisms of action of sildenafil citrate in human chorionic arteries.
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