TNFSF11 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human TNFSF11 protein.
Immunogen
TNFSF11 (ENSP00000351347, 1 a.a. ~ 244 a.a) full-length human protein.
Sequence
MDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (85)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of TNFSF11 expression in transfected 293T cell line (H00008600-T01) by TNFSF11 MaxPab polyclonal antibody.
Lane 1: TNFSF11 transfected lysate(27.70 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — TNFSF11
Entrez GeneID
8600GeneBank Accession#
NM_033012Protein Accession#
ENSP00000351347Gene Name
TNFSF11
Gene Alias
CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
Gene Description
tumor necrosis factor (ligand) superfamily, member 11
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq
Other Designations
OTTHUMP00000178585|TNF-related activation-induced cytokine|osteoclast differentiation factor|osteoprotegerin ligand|receptor activator of nuclear factor kappa B ligand|tumor necrosis factor ligand superfamily, member 11
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Interactome
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Pathway
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Disease
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