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Last updated: 2016/12/4
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TNFSF11 (Human) Matched Antibody Pair

  • Catalog # : H00008600-AP41
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  • Specification
  • Product Description:
  • This antibody pair set comes with matched antibody pair to detect and quantify protein level of human TNFSF11.
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Standard curve using mammalian expressed recombinant protein as an analyte.

    QC Testing of H00008600-AP41
    Sandwich ELISA detection sensitivity ranging from 3 ng/ml to 100 ng/ml.
  • Supplied Product:
  • Antibody pair set content:
    1. Capture antibody: mouse monoclonal anti-TNFSF11, IgG1 Kappa (100 ug)
    2. Detection antibody: biotinylated mouse monoclonal anti-TNFSF11, IgG1 Kappa (50 ug)
    *Reagents are sufficient for at least 3-5 x 96 well plates using recommended protocols.
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Applications
  • Application Image
  • ELISA Pair (Recombinant protein)
  • Gene Information
  • Entrez GeneID:
  • 8600
  • Gene Name:
  • TNFSF11
  • Gene Alias:
  • CD254,ODF,OPGL,OPTB2,RANKL,TRANCE,hRANKL2,sOdf
  • Gene Description:
  • tumor necrosis factor (ligand) superfamily, member 11
  • Gene Summary:
  • This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000178585,TNF-related activation-induced cytokine,osteoclast differentiation factor,osteoprotegerin ligand,receptor activator of nuclear factor kappa B ligand,tumor necrosis factor ligand superfamily, member 11
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