HAT1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human HAT1 full-length ORF ( AAH63003, 1 a.a. - 334 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYTEFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLPCFSREKLMQGFNEDMAIEAQQKFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLISPYKKKQRDLAKMRKCLRPEELTNQMNQIEISMQHEQLEESFQELVEDYRRVIERLAQE
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
62.48
Interspecies Antigen Sequence
Mouse (93); Rat (96)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — HAT1
Entrez GeneID
8520GeneBank Accession#
BC063003Protein Accession#
AAH63003Gene Name
HAT1
Gene Alias
KAT1
Gene Description
histone acetyltransferase 1
Omim ID
603053Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense.
Yukang Yuan, Ying Miao, Liping Qian, Yang Zhang, Chao Liu, Jin Liu, Yibo Zuo, Qian Feng, Tingting Guo, Liting Zhang, Xiangjie Chen, Lincong Jin, Fan Huang, Hongguang Zhang, Wei Zhang, Wei Li, Guoqiang Xu, Hui Zheng.
Molecular Cell 2020 Feb; 77(4):734.
Application：In Vitro Acetylation Assay, Human, HEK 293T cells.
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Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense.
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