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PPM1D Pre-design Chimera RNAi

  • Catalog # : H00008493-R02
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  • Specification
  • Product Description:
  • Homo sapiens protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_003620
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 8493
  • Gene Name:
  • PPM1D
  • Gene Alias:
  • PP2C-DELTA,WIP1
  • Gene Description:
  • protein phosphatase 1D magnesium-dependent, delta isoform
  • Gene Summary:
  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq
  • Other Designations:
  • p53-induced protein phosphatase 1,protein phosphatase 1D,protein phosphatase 2C delta isoform,protein phosphatase Wip1
  • Gene Pathway
  • Related Disease
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