Products

Western Blot (Transfected lysate)

Western Blot analysis of PPM1D expression in transfected 293T cell line by PPM1D monoclonal antibody (M01), clone 4D1.

Lane 1: PPM1D transfected lysate(66.7 KDa).
Lane 2: Non-transfected lysate.

Western Blot (Recombinant protein)

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged PPM1D is approximately 0.1ng/ml as a capture antibody.

ELISA

Entrez GeneID

8493

GeneBank Accession#

NM_003620

Protein Accession#

NP_003611

Gene Name

PPM1D

Gene Alias

PP2C-DELTA, WIP1

Gene Description

protein phosphatase 1D magnesium-dependent, delta isoform

Omim ID

114480 605100

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq

Other Designations

p53-induced protein phosphatase 1|protein phosphatase 1D|protein phosphatase 2C delta isoform|protein phosphatase Wip1