CILP (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human CILP partial ORF ( NP_003604, 129 a.a. - 226 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
NCSNYTVRFLCPPGSLRRDTERIWSPWSPWSKCSAACGQTGVQTRTRICLAEMVSLCSEASEEGQHCMGQDCTACDLTCPMGQVNADCDACMCQDFML
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.52
Interspecies Antigen Sequence
Mouse (88); Rat (88)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CILP
Entrez GeneID
8483GeneBank Accession#
NM_003613Protein Accession#
NP_003604Gene Name
CILP
Gene Alias
CILP-1, HsT18872
Gene Description
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Gene Ontology
HyperlinkGene Summary
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase, however later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. One isoform of the protein, CILP-1, functions as an IGF-1 antagonist. [provided by RefSeq
Other Designations
cartilage intermediate layer protein|cartilage intermediate layer protein 1 C1|cartilage intermediate layer protein 1 C2
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Interactome
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Disease
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