NR0B2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
SDS-PAGE Gel
NR0B2 transfected lysate.
Western Blot
Lane 1: NR0B2 transfected lysate ( 28.1 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-NR0B2 full-length
Host
Human
Theoretical MW (kDa)
28.1
Interspecies Antigen Sequence
Mouse (78); Rat (78)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-NR0B2 antibody (H00008431-B01) by Western Blots.
SDS-PAGE Gel
NR0B2 transfected lysate.
Western Blot
Lane 1: NR0B2 transfected lysate ( 28.1 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — NR0B2
Entrez GeneID
8431GeneBank Accession#
NM_021969.1Protein Accession#
-Gene Name
NR0B2
Gene Alias
FLJ17090, SHP, SHP1
Gene Description
nuclear receptor subfamily 0, group B, member 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq
Other Designations
OTTHUMP00000004414|orphan nuclear receptor SHP|short heterodimer partner|small heterodimer partner
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Interactome
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Disease
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