FZD8 (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human FZD8 partial ORF ( NP_114072, 72 a.a. - 161 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
FWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
35.64
Interspecies Antigen Sequence
Mouse (100); Rat (100)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — FZD8
Entrez GeneID
8325GeneBank Accession#
NM_031866Protein Accession#
NP_114072Gene Name
FZD8
Gene Alias
FZ-8, hFZ8
Gene Description
frizzled homolog 8 (Drosophila)
Omim ID
606146Gene Ontology
HyperlinkGene Summary
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq
Other Designations
OTTHUMP00000019454|frizzled 8
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Interactome
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Pathway
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Disease
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