FZD7 (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human FZD7 partial ORF ( NP_003498.1, 155 a.a. - 253 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
GAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.63
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — FZD7
Entrez GeneID
8324GeneBank Accession#
NM_003507Protein Accession#
NP_003498.1Gene Name
FZD7
Gene Alias
FzE3
Gene Description
frizzled homolog 7 (Drosophila)
Omim ID
603410Gene Ontology
HyperlinkGene Summary
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq
Other Designations
Frizzled, drosophila, homolog of, 7|frizzled 7
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Interactome
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Pathway
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Disease
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