CDC45L (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human CDC45L partial ORF ( NP_003495, 477 a.a. - 566 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
FVCSTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLLS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
35.64
Interspecies Antigen Sequence
Mouse (93); Rat (96)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CDC45L
Entrez GeneID
8318GeneBank Accession#
NM_003504Protein Accession#
NP_003495Gene Name
CDC45L
Gene Alias
CDC45, CDC45L2, PORC-PI-1
Gene Description
CDC45 cell division cycle 45-like (S. cerevisiae)
Omim ID
603465Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported. [provided by RefSeq
Other Designations
CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like|CDC45-like|CDC45-related protein|cell division cycle 45-like 2|human CDC45
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Interactome
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Disease
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