SERF1A DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human SERF1A DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MARGNQRELARQKNMKKTQEISKGKRKEDSLTASQRKQSSGGQKSESKMSAGPHLPLKAPRENPCFPLPAAGGSRYYLAYGSITPISAFVFVVFFSVFFPSFYEDFCCWI
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — SERF1A
Entrez GeneID
8293GeneBank Accession#
NM_021967.1Protein Accession#
NP_068802.1Gene Name
SERF1A
Gene Alias
4F5, FAM2A, H4F5, SERF1, SMAM1
Gene Description
small EDRK-rich factor 1A (telomeric)
Omim ID
603011Gene Ontology
HyperlinkGene Summary
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The duplication region includes both a telomeric and a centromeric copy of this gene. Deletions of this gene, the telomeric copy, often accompany deletions of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients, and so it is thought that this gene may be a modifier of the SMA phenotype. The function of this protein is not known; however, it bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. [provided by RefSeq
Other Designations
SMA modifier 1|small EDRK-rich factor 1A, telomeric|spinal muscular atrophy-related gene H4F5
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Interactome
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Disease
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