PSCA monoclonal antibody (M03), clone 5C2
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant PSCA.
Immunogen
PSCA (NP_005663, 23 a.a. ~ 95 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
CYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNAS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (66); Rat (68)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (33.77 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of PSCA expression in transfected 293T cell line by PSCA monoclonal antibody (M03), clone 5C2.
Lane 1: PSCA transfected lysate(12.9 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PSCA is 0.1 ng/ml as a capture antibody.ELISA
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Gene Info — PSCA
Entrez GeneID
8000GeneBank Accession#
NM_005672Protein Accession#
NP_005663Gene Name
PSCA
Gene Alias
PRO232
Gene Description
prostate stem cell antigen
Omim ID
602470Gene Ontology
HyperlinkGene Summary
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene has a nonsynonymous nucleotide polymorphism at its start codon. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Pre-conditioning Modifies the Tumor Microenvironment to Enhance Solid Tumor CAR T Cell Efficacy and Endogenous Protective Immunity.
John P Murad, Dileshni Tilakawardane, Anthony K Park, Lupita S Lopez, Cari A Young, Jackson Gibson, Yukiko Yamaguchi, Hee Jun Lee, Kelly T Kennewick, Brenna J Gittins, Wen-Chung Chang, Chau P Tran, Catalina Martinez, Anna M Wu, Robert E Reiter, Tanya B Dorff, Stephen J Forman, Saul J Priceman.
Molecular Therapy 2021 Jul; 29(7):2335.
Application:IHC-P, Mouse, Mouse tumors.
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EXTRACELLULAR AND MEMBRANE-ASSOCIATED PROSTATE CANCER MARKERS.
George G. Klee, George Vasmatzis, Farhad Kosari, Eric W. Klee
United States Patent Application Publication 2010 Feb; [Epub].
Application:Array, Mammal, Prostate cancer.
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Pre-conditioning Modifies the Tumor Microenvironment to Enhance Solid Tumor CAR T Cell Efficacy and Endogenous Protective Immunity.
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